More on relative usefulness of two tests for occult blood in stool.

Although the clinical significance of CK-BB is not now fully understood, reports show that serum CK-BB is found in association with neoplastic disease of the stomach and prostate (12, 13). The recent finding of a higher concentration of CK-BB in medullary serum relative to that of peripheral serum (14) may lead to assays for CK-BB that are useful in the early diagnosis of metastatic disease involving bone. Because of the relatively low concentration of CK-BB in most tissues, a sensitive method that is free of interference must be used to detect its activity in serum. The paperoverlay technique accomplishes this quite well. With a reliable method for identifying the CK-BB isoenzyme, a better appreciation of its clinical significance can be expected.